Abstract
2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency, efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. alpha(1A)-subtype selective agonists have been identified.
MeSH terms
-
Adrenergic alpha-1 Receptor Agonists
-
Adrenergic alpha-Agonists / chemistry
-
Adrenergic alpha-Agonists / pharmacology*
-
Amides / chemistry
-
Carboxylic Acids / chemistry*
-
Esters / chemistry
-
Imidazoles / chemistry
-
Imidazoles / pharmacology*
-
Structure-Activity Relationship
Substances
-
Adrenergic alpha-1 Receptor Agonists
-
Adrenergic alpha-Agonists
-
Amides
-
Carboxylic Acids
-
Esters
-
Imidazoles